This book provides basics and selected advanced insights on how to generate reliability, safety and resilience within (socio) technical system developments. The focus is on working definitions, fundamental development processes, safety development processes and analytical methods on how to support such schemes. The method families of Hazard Analyses, Failure Modes and Effects Analysis and Fault Tree Analysis are explained in detail. Further main topics include semiformal graphical system modelling, requirements types, hazard log, reliability prediction standards, techniques and measures for reliable hardware and software with respect to systematic and statistical errors, and combination options of methods. The book is based on methods as applied during numerous applied research and development projects and the support and auditing of such projects, including highly safety-critical automated and autonomous systems. Numerous questions and answers challenge students and practitioners.