Drawing on expertise from communication scholars who examine resilience within and across individual, relational, group/team, organizational, inter-organizational, and community levels, this handbook provides a wide-ranging resource for theory building, empirical investigations, and practical applications. Chapters in this handbook bring awareness to how resilience is constituted through human communication processes. As a baseline, Part I begins with chapters that explicate and conceptualize resilience as a process that shapes and reflects communication behavior at multiple levels. In Part II, chapters focus on micro communication processes in the enactment of resilience at an interpersonal level in domains such as close relationships, families, and small groups. In Part III, attention shifts toward examining resilience processes in professional domains within and among organizations. Part IV considers macro communication processes, looking at how communities can build resilience, sustainability, and engagement through communal activities that cultivate strong networks and promote the health and safety of the community All chapters feature a discussion of practical implications for policy investments and/or interpersonal interventions for building and maintaining sustainability and resiliency. This handbook is a useful resource for scholars and advanced students in communication studies, social psychology, sociology, human development, public policy, and family sciences.