This book constitutes the refereed proceedings of the 19th International Semantic Web Conference, ESWC 2022, held in Hersonissos, Crete, Greece in May/June 2022.

The 28 full papers presented were carefully reviewed and selected from 119 submissions. The papers are covering subjects related to semantic technologies, ranging from deep learning and knowledge graphs to integration for software development and ontologies.

The quality of the accepted papers put the maturity level reached by the Semantic Web technologies into perspective. They provide evidence of the impact of these technologies in areas like data management, question answering, reasoning, programming languages, and machine learning.