This two-volume set LNCS 15718-15719 constitutes the refereed proceedings of the 22nd European Semantic Web Conference, ESWC 2025, held in Portoroz, Slovenia, during June 1–5, 2025. The 45 full papers presented were carefully reviewed and selected from 155 submissions.The ESWC’s Research track addresses the theoretical, analytical, and empirical aspects of the semantic web, semantic technologies, knowledge graphs and semantics on the Web in general. The In-use track focuses on contributions that reuse and apply state-of-the-art semantic technologies or resources to real-world settings. The resource track deals with resource contributions that are, on the one hand innovative or novel, and on the other hand sharable and reusable (e.g. datasets, knowledge graphs, ontologies, workflows, benchmarks, frameworks), and provide the necessary scaffolding to support the generation of scientific work and advance the state of the art.