Engaging clients in occupation and activities to promote health and well-being is a fundamental principle of occupational therapy. The fifth edition of The Texture of Life clearly defines the importance of occupation through the lens of the Occupational Therapy Practice Framework and describes the relationship between occupations and their related activities. An ideal foundational textbook for occupational therapy students and practitioners, The Texture of Life gives an in-depth exploration of occupation in the context of theoretical perspectives; history; activity analysis and synthesis; professional reasoning; self-care, leisure, work, and care of others; independence; and spirituality. This new edition emphasizes culture and society, the increased importance of work with groups and communities, and changes in practice since the COVID-19 pandemic. A new chapter on occupational therapy history connects contemporary, occupation-based practice to the profession’s historical roots. Exercises and case examples challenge students and experienced practitioners alike to think critically about occupation and transfer new knowledge into actual practice.