This book introduces the Topological Weighed Centroid approach and describes some applications in the study of the dynamics of various spatial phenomena with a special emphasis on the spatial analysis of the relationship, influence, and dynamics of geographical phenomena. Offering a comprehensive introduction to the theory and illustrative examples from various kinds of geographical data, this book also takes an in-depth look at more complex case studies, such as the applications of the topological weighed centroid approach in the study of epidemic patterns, cultural processes, criminality, and environmental phenomena.