This book provides up-to-date information on the mechanisms of protein degradation and highlights the significance of protein quality control for cellular physiology and pathology specifically in CNS neurodegenerative diseases. Chapters cover cellular bioenergetics, environmental factors, protein load, and their respective roles in the pathogenesis and progression of diseases. Additionally, the book addresses the array of experimental tools (models) available for studying disease etiology, progression, and therapeutics, offering a balanced discussion of their advantages and disadvantages. It provides insights into the effects of both sporadic and genetic models in investigating disease mechanisms, with a perspective on experimental model systems. The book is relevant for scientists and researchers in the fields of neuroscience, cellular signaling, protein, and systems biology. It is also valuable for clinicians interested in both basic and translational research in the field of central nervous system (CNS) neurodegenerative diseases.