Fracture, Fatigue, Failure, Damage Evolution and Thermomechanics & Infrared Imaging, Volume 4 of the Proceedings of the 2025 SEM Annual Conference & Exposition on Experimental and Applied Mechanics, the fourth volume of five from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of areas, including:3D Deformation and FailureIn-situ Techniques and Microscale Effects on Mechanical BehaviorVibration and Cyclic FatigueIntegration of Models and ExperimentsInterface-Mediated Damage and FailureFracture and Fatigue in Brittle MaterialsMaterial Characterizations Using ThermographyFatigue, Damage & Fracture Evaluation Using Infrared Thermography