This book covers areas such as information technology in engine design and production; information technology in the creation of rocket and space systems; aerospace engineering; transport systems and logistics; big data and data science; nanomodeling; artificial intelligence and intelligent systems; networks and communications; cyber-physical systems and IoE; as well as software engineering and IT infrastructure. The materials were tested during the International Scientific and Technical Conference “Integrated Computer Technologies in Mechanical Engineering”—Synergetic Engineering (ICTM) was established by the National Aerospace University “Kharkiv Aviation Institute.”The ICTM’2025 conference was held in Kharkiv, Ukraine, in November 2025. During this conference, technical exchange between the scientific community was carried out in the form of keynote speeches, panel discussions, and a special session. More than 100 papers from different countries were received at ICTM’2025. This book offers us a lot of valuable information and is very useful for the exchange of experience between scientists in the field of modeling and simulation. ICTM was created to bring together outstanding researchers and practitioners in the field of information technology in the design and manufacture of engines; the creation of rocket and space systems, aerospace engineering from all over the world to exchange experiences and expertise.