This book offers a comprehensive, interdisciplinary framework for addressing the global burden of Major Depressive Disorder (MDD). Bridging neuroscience, mental health, and policy, this volume responds to the urgent need for integrated disability care, particularly in the wake of a post-COVID-19 surge in MDD cases worldwide. The book explores advanced neurobiological insights, such as prefrontal-limbic dysfunction and fMRI-guided interventions, alongside evidence-based mental health strategies, including stigma reduction, cognitive-behavioral therapies, and digital health tools. Emphasizing person-centered care, it provides practical guidance for curriculum development, telehealth integration, and empowerment-driven approaches, with a focus on equity and access in low-resource settings. Structured across seven chapters, the volume covers foundational disability care, neurological and mental health perspectives, systems-based integration, person-centered models, empowerment strategies, and policy innovations. Designed for clinicians, educators, researchers, and policymakers, this SpringerBrief equips readers with actionable tools to enhance resilience, recovery, and inclusive care for individuals living with MDD-related disability. By combining rigorous science, innovative practice, and policy reform, this book fills critical gaps in the literature and serves as an essential resource for advancing disability care in mental health globally.