This book addresses how decision-makers can respond to cross-sector challenges that become prevalent in the wake of global crises. The recent COVID-19 pandemic is one such example of an ongoing global crisis with multifaceted dimensions. As it unfolded on top of a range of pre-existing health, socio-political and economic crises, the pandemic forced every company to adapt to every twist and turn. Similarly, most crises call for institutions to be flexible and agile to meet the challenges head on. Through case studies rooted in real life scenarios, this book seeks to highlight the most critical questions that leaders need to ask and answer: What might not and should not return to normal? What are the new superior ways of operating during such times in contrast to the old routines? By answering these questions, leaders will learn to reorient, rediscover, and restructure existing practices to manage their businesses effectively.