This book examines and summarises the developments and changes in the approach of organic and natural product chemists over the past years, presenting both the successes and inevitable missteps. These illustrate the process from molecular isolation and structural identification, synthesis and biosynthesis and future perspectives, including the development of biological engineering. The anticipated audience are chemistry-literate scientists who are interested both in specific aspects of natural product chemistry and the illustrative process of trial, error and success which defines the area.