This text serves as a high-yield review of spinal cord injury medicine in a multiple choice question-based format. The content covered reflects key topics relevant to clinical practice and subspecialty certification through the American Board of Physical Medicine and Rehabilitation (ABPMR) Spinal Cord Injury (SCI) Medicine examination. The 22 chapters are arranged topically to address the full scope of information relevant to the field of spinal cord injury medicine. Included with each question is a corresponding in-depth explanation, as well as pertinent references to supporting literature. The questions and educational explanations are written by leading experts in the field of spinal cord injury medicine and are designed to be board-relevant in both content and style. This question bank should be of use to anyone wishing to test and expand their knowledge of spinal cord injury medicine, including therapists, medical students, residents, fellows, and attending physicians of any specialty.