This handbook will raise awareness about the importance of health and well-being of people with disabilities in the context of the global development agenda: Leaving No-one Behind. There has been a growing discussion on how people with disabilities should be included in the global health landscape. An estimated one billion people have some form of disability, 80% of whom live in low- and middle-income settings. People with disabilities are more likely to be poor, with restricted access to health and social services, education, rehabilitation and employment. Despite this, people with disabilities are often overlooked in global health and development efforts. Furthermore, the COVID-19 pandemic has shown that unless systematically planned for and included in policies and programmes, people with disabilities remain at an increased risk of being adversely affected in times of humanitarian crisis and emergency disasters. Divided into eight sections:Disability and Health FrameworksHealth Justice, Rights and BioethicsGendering Disability HealthDisability and Global Mental HealthDisability and Access to Healthcare, Including Workforce DevelopmentCrises and HealthTechnology and Digital HealthDisability, Ageing and Dementia CareThis handbook covers the full range of topics pertaining to disability and global health including inclusive health; access to rehabilitation; global mental health and disability; medical training and disability; community based inclusive development for improving health and rehabilitation; maternal health and sexual reproduction; preventive care and health promotion for people with disabilities; health, disability and indigenous knowledges; bioethics and human rights; data protection; and health in the global south. It will be of interest to all scholars, students and professionals working in the fields of disability studies, health studies, nursing, medicine, allied health, development studies and sociology.