This guide provides a comprehensive overview of High Performance Computing (HPC) to equip students with a full skill set including cluster setup, network selection, and a background of supercomputing competitions. It covers the system, architecture, evaluating approaches, and other practical supercomputing techniques. As the world’s largest supercomputing hackathon, the ASC Student Supercomputer Challenge has attracted a growing number of new talent to supercomputing and has greatly promoted communications in the global HPC community. Enclosed in this book, readers will also find how to analyze and optimize supercomputing systems and applications in real science and engineering cases.