This book is concerned with “How to provide guidance for small cultural heritage institutions to govern digital transformation, and how to align the possibilities with the available capabilities by creating a Software Framework for Mobile Apps in the Museum Application Domain?”. The role of the museum has shifted from a keeper of artifacts to a provider of information. In this context mobile applications are intended to generate added value for the museum visitor. However, the tension between the application’s creator, its content, and the consumer operating the app needs to be examined holistically. As it is not trivial to create an integrated user experience, the unique usability-centered perspective on the requirements engineering pursued throughout, allows for the suggested data-driven solution to address the specific domain issues and serve the intended audience. Based on the insights gained during this examination and under the utilization of design science research, human-centered design, and domain-driven design “A Software Framework for Mobile Apps in the Museum Application Domain” is created and implemented using web technologies.