The four-volume set LNAI 15819–15822 constitutes the thoroughly refereed proceedings of the 6th International Conference on Artificial Intelligence in HCI, AI-HCI 2025, held as part of the 27th International Conference, HCI International 2025, which took place in Gothenburg, Sweden, June 22-17, 2025. The total of 1430 papers and 355 posters included in the HCII 2025 proceedings was carefully reviewed and selected from 7972 submissions. The papers have been organized in topical sections as follows: Part I: Trust and Explainability in Human-AI Interaction; User Perceptions, Acceptance, and Engagement with AI; UX and Socio-Technical Considerations in AIPart II: Bias Mitigation and Ethics in AI Systems; Human-AI Collaboration and Teaming; Chatbots and AI-Driven Conversational Agents; AI in Language Processing and Communication. Part III: Generative AI in HCI; Human-LLM Interactions and UX Considerations; Everyday AI: Enhancing Culture, Well-Being, and Urban Living. Part IV: AI-Driven Creativity: Applications and Challenges; AI in Industry, Automation, and Robotics; Human-Centered AI and Machine Learning Technologies.