This two-volume set LNAI 14844-14845 constitutes the refereed proceedings of the 22nd International Conference on Artificial Intelligence in Medicine, AIME 2024, held in Salt Lake City, UT, USA, during July 9-12, 2024. The 54 full papers and 22 short papers presented in the book were carefully reviewed and selected from 335 submissions. The papers are grouped in the following topical sections:Part I: Predictive modelling and disease risk prediction; natural language processing; bioinformatics and omics; and wearable devices, sensors, and robotics. Part II: Medical imaging analysis; data integration and multimodal analysis; and explainable AI.