The four-volume set LNCS 16068-16071 constitutes the proceedings of the 34th International Conference on Artificial Neural Networks and Machine Learning, ICANN 2025, held in Kaunas, Lithuania, September 9–12, 2025. The 170 full papers and 8 abstracts included in these conference proceedings were carefully reviewed and selected from 375 submissions. The conference strongly values the synergy between theoretical progress and impactful real-world applications, and actively encourages contributions that demonstrate how artificial neural networks are being used to address pressing societal and technological challenges.