Although there is broad agreement that research should inform the instruction of students with learning and behavioral disabilities, implementation of research-based practices in real schools and classrooms is a nuanced endeavor, fraught with challenges. This volume of case studies illuminates the realities and complexities of implementing research-based instructional programs and practices targeting improved behavioral outcomes in real-world settings. The case studies featured in each chapter are authored or co-authored by educators who are or who have recently been in the classroom and highlights their experiences in critical stages of implementing evidence-based practices, such as selection of the practice (e.g., evaluation of evidence, alignment with learner needs and characteristics, consideration of resources), implementation of the practices (e.g., training and supports, challenges/difficulties, fidelity and adaptations), evaluation of effects, and long-term implementation and impacts. Recommendations for implementing the targeted practice are suggested, and collectively the case studies in this volume provide educators of students with learning and behavioral disabilities with lessons to inform the implementation of research-based practices.