This book is devoted to new approaches to modeling and design of cyber-physical systems. Nowadays, cyber-physical systems become widely used in different domains. Scientific society suggests new approaches to engineering and optimization of cyber-physical systems, however, there are still open questions that need to be covered by research and development. It presents results and findings in the field of Data Science and digital twin engineering for cyber-physical systems. This book provides scientific, practical, and methodological approaches to modeling of complex processes for cyber-physical systems. The authors highlight essential results on software optimization in cyber-physical systems. The target audience of the book are practitioners, enterprise representatives, scientists, Ph.D., and master’s students who perform scientific research or applications of cyber-physical systems for various domains.