The two-volume set LNCS 14910 and 14911 constitutes the proceedings of the 35th International Conference on Database and Expert Systems Applications, DEXA 2024, which took place in Naples, Italy, in August 2024. The 27 full and 20 short papers included in the proceedings set were carefully reviewed and selected from 102 submissions. They were organized in topical sections as follows:Part I: Financial and economic data analysis; graph theory and network analysis; database management and query optimization; machine learning and large language models; recommender systems and personalization;Part II: Blockchain and supply management; data mining and knowledge discovery; spatiotemporal data and mobility analysis; computer vision and image processing; data security and privacy; database indexing and query processing; specialized applications and case studies.