This three-volume set LNCS 15791-15793 constitutes the refereed proceedings of the 16th International Conference on Digital Human Modeling and Applications in Health, Safety, Ergonomics and Risk Management, DHM 2025, held as part of the 27th International Conference on Human-Computer Interaction, HCII 2025, in Gothenburg, Sweden, during June 22-27, 2025. The total of 1430 papers and 355 posters included in the HCII 2025 proceedings was carefully reviewed and selected from 7972 submissions. The three volumes cover the following topics:Part I: Digital human modeling for healthcare and wellbeing; AI and digital human modeling in safety and risk management; and biomechanics, ergonomics, and risk mitigation. Part II: User experience design for sustainable products and public spaces; and wearable and digital health monitoring. Part III: Healthcare and rehabilitation innovation; augmented and virtual reality for health, wellbeing, and digital human modeling; and behavioral modeling and human-technology interaction.