This book constitutes the refereed proceedings of the 27th International Conference on Enterprise Design, Operations, and Computing, EDOC 2023, held in Groningen, The Netherlands, during October 30–November 3, 2023. The 12 full papers included in this book were carefully reviewed and selected from 36submissions. They were organized in topical sections as follows: Enterprise Modeling, Enterprise Architecture & Engineering, Model-Based Software Engineering, Enterprise Analysis with Process Mining, Process Improvement & Engineering, and Modeling in an Enterprise Context.