This book constitutes the refereed proceedings of the 22nd International Symposium on Formal Methods, FM 2018, held in Oxford, UK, in July 2018. The 44 full papers presented together with 2 invited papers were carefully reviewed and selected from 110 submissions. They present formal methods for developing and evaluating systems. Examples include autonomous systems, robots, and cyber-physical systems in general. The papers cover a broad range of topics in the following areas: interdisciplinary formal methods; formal methods in practice; tools for formal methods; role of formal methods in software systems engineering; and theoretical foundations.