Evolving technological advancements in big data, smartphone and mobile software applications, the Internet of Things and a vast range of application areas in all sorts of human activities and professions, lead current research toward the efficient incorporation of artificial intelligence enhancements into software and the empowerment of software with artificial intelligence. The book at hand, devoted to Smart Software Applications in Cyber-Physical Systems, constitutes the second volume of a two-volume Handbook on Artificial Intelligence-empowered Applied Software Engineering. Topics include very significant advances in Smart Software Applications in (i) Scientific Document Processing, (ii) Enterprise Modeling, (iii) Education, (iv) Health care and Medicine, and (v) Infrastructure Monitoring. Professors, researchers, scientists, engineers, and students in artificial intelligence, software engineering, andcomputer science-related disciplines are expected to benefit from it, along with interested readers from other disciplines.