This book covers the following main topics:  A) information and knowledge management; B) organizational models and information systems; C) software and systems modeling; D) software systems, architectures, applications and tools; E) multimedia systems and applications; F) computer networks, mobility and pervasive systems; G) intelligent and decision support systems; H) big data analytics and applications; I) human–computer interaction; J) ethics, computers and security; K) health informatics; L) information technologies in education; M) information technologies in radio communications; N) technologies for biomedical applications. This book is composed by a selection of articles from The 2022 World Conference on Information Systems and Technologies (WorldCIST'22), held between April 12 and 14, in Budva, Montenegro. WorldCIST is a global forum for researchers and practitioners to present and discuss recent results and innovations, current trends, professional experiences, and challenges of modern information systems and technologies research, together with their technological development and applications.