This two-volume set LNCS 15762-15763 constitutes the proceedings of the 22nd International Conference on the Integration of Constraint Programming, Artificial Intelligence, and Operations Research, CPAIOR 2025, held in Melbourne, VIC, Australia, November 10–13, 2025. The 30 full papers and the 2 short papers presented in the proceedings were carefully reviewed and selected from a total of 68 submissions. The conference featured a masterclass and several joint invited talks that covered topics of interest at the intersection of constraint programming, artificial Intelligence, operations research, planning and scheduling, and knowledge representation.