The two-volume proceedings set CCIS 2121 and 2122 constitutes the refereed proceedings of the First International Conference on Intelligent Computing for Sustainable Development, ICICSD 2023, which took place in Hyderabad, India, during August 25–26, 2023. The 46 papers included in these proceedings were carefully reviewed and selected from 138 submissions. They focus on digital healthcare, renewable energy, smart cities, digital farming, and autonomous systems.