This book includes the scientific results of the fourth edition of the International Conference on Intelligent Computing and Optimization which took place at December 30–31, 2021, via ZOOM. The conference objective was to celebrate “Compassion and Wisdom” with researchers, scholars, experts and investigators in Intelligent Computing and Optimization worldwide, to share knowledge, experience, innovation—marvelous opportunity for discourse and mutuality by novel research, invention and creativity. This proceedings encloses the original and innovative scientific fields of optimization and optimal control, renewable energy and sustainability, artificial intelligence and operational research, economics and management, smart cities and rural planning, meta-heuristics and big data analytics, cyber security and blockchains, IoTs and Industry 4.0, mathematical modelling and simulation, health care and medicine.