This book presents the outcomes of the second edition of the International Conference on Intelligent Computing and Optimization (ICO) – ICO 2019, which took place on October 3–4, 2019, in Koh Samui, Thailand. Bringing together research scholars, experts, and investigators from around the globe, the conference provided a platform to share novel research findings, recent advances and innovative applications in the field. Discussing the need for smart disciplinary processes embedded into interdisciplinary collaborations in the context of meeting the growing global populations’ requirements, such as food and health care, the book highlights the role of intelligent computation and optimization as key technologies in  decision-making processes and in providing cutting edge solutions to real-world problems.