This book constitutes the refereed proceedings of the 8th International Workshop, iMIMIC 2025, held in Conjunction with MICCAI 2025, in Daejeon, South Korea, on September 27, 2025. The 15 full papers included in this volume were carefully reviewed and selected from 22 submissions. The iMIMIC papers focus on introducing the challenges and opportunities related to the topic of interpretability of machine learning systems in the context of medical imaging and computer assisted intervention.