This book constitutes the refereed proceedings of the 12th International Conference on Learning Technology for Education Challenges, LTEC 2024, held in Kaohsiung, Taiwan, during July 29–August 1, 2024. The 26 full papers included in this book were carefully reviewed and selected from 51 submissions. They were organized in topical sections as follows: serious games and virtual learning environments; learning practices and methodologies; learning technologies; learning processes and culture; e-learning and performance, and artificial intelligence and learning.