This book is a collection of peer-reviewed best selected research papers presented at the Second International Conference on Machine Intelligence and Smart Systems (MISS 2021), organized during September 24–25, 2021, in Gwalior, India. The book presents new advances and research results in the fields of machine intelligence, artificial intelligence and smart systems. It includes main paradigms of machine intelligence algorithms, namely (1) neural networks, (2) evolutionary computation, (3) swarm intelligence, (4) fuzzy systems and (5) immunological computation. Scientists, engineers, academicians, technology developers, researchers, students and government officials will find this book useful in handling their complicated real-world issues by using machine intelligence methodologies.