This proceedings volume gathers selected, carefully reviewed works presented at the Portugal-Italy Conference on Nonlinear Differential Equations and Applications (PICNDEA22), held on July 4-6, 2022, at the University of Évora, Portugal. The main focus of this work lies in non-linear problems originating in applications and their treatment with numerical analysis. The reader will also find new advances on topics such as ordinary and partial differential equations, numerical analysis, topological and variational methods, fluid mechanics, operator theory, stability, and more. The Portugal-Italy Conference on Nonlinear Differential Equations and Applications convenes Italian and Portuguese researchers in differential equations and their applications to amplify previous collaboration and to follow and discuss new topics in the area. Reflecting the increasing teamwork involving the two mathematical communities, the conference has been opened to researchers from all nationalities. While researchers in analysis and related fields are the primary readership of this volume, PhD students can rely on this book as a valuable source to keep pace with recent advances in differential equations and cutting-edge applications.