The two volume set LNCS 15937 + 15938 constitutes the proceedings of the 12th Iberian Conference on Pattern Recognition and Image Analysis, IbPRIA 2025, which took place in Coimbra, Portugal, during June 30–July 3, 2025. The 67 full papers included in the proceedings were carefully reviewed and selected from 115 submissions. They were organized in topical sections as follows:Part I: Computer vision; faces, body, fingerprints and biometrics; machine and deep learning; explainability, bias and fairness in DL;Part II: Natural language processing; biomedical applications; and other applications.