This three-volume set constitutes the refereed proceedings of the 51st Euromicro Conference on Software Engineering and Advanced Applications, SEAA 2025, held in Salerno, Italy, during September 10-12, 2025. The 62 full papers were carefully reviewed and selected from 177 submissions.These papers were organized in the following topical sections:Part I: Data and AI Driven Engineering; Cyber-Physical Systems; Model-Driven Engineering and Modeling Languages. Part II: Practical Aspects of Software Engineering; Systematic Literature Reviews and Mapping Studies in Software Engineering. Part III: Software Management: Measurement, Peopleware, and Innovation; Software Process and Product Improvement; Software Analytics: Mining Software Open Datasets and Repositories; Emerging Computing Technologies.