This comprehensive work examines the opioid epidemic through a family-centered lens, shifting the focus from how adults have been harmed by opioids to the broader impact of the drugs on children, families, and communities. The book traces opioids’ complex history and unfulfilled medical promise, analyses systemic failures that fueled the current crisis, and highlights the particularly devastating impact on vulnerable populations—especially children. Through comparative analysis of international approaches and historical contexts, the author identifies overlooked solutions and opportunities for meaningful interventions. Chapters bring together the current research, including a history of opioids, their harmful effects, where advances have been made and challenges persist, and what can be done to improve safety. Practical steps for families and their healthcare providers are presented along with strategies for building resilience. Written for healthcare professionals, policy makers, government officials, community leaders, and most importantly, families affected by opioids, Living with Opioids, offers practical strategies for families, communities, and institutions to strengthen the capacity to protect themselves, create safer home environments, and learn to coexist with these powerful substances in our society.