This book covers the clinical application of nano-biomaterials in hard tissue repair and regeneration which are materials designed to interact with biological systems to restore and regenerate damaged tissues. These materials serve as scaffolds that mimic the natural extracellular matrix (ECM), providing structural support and biochemical cues necessary for cellular activities. The physical and chemical properties of biomaterials can be tailored to specific applications, such as bone regeneration, cartilage repair, wound healing, and organ transplantation. Biomaterials influence cell behavior and tissue formation by controlling factors like mechanical strength, porosity, and surface topography. This books is suitable to students, academics, and clinical practitioners who are interested in the advancements of regenerative medicine.