This book is devoted to strengthening the theoretical and methodological basis, systematization of international experience, and scientific elaboration of prospects for developing a climate-smart economy and business as a vector of the sustainable development of Industry 4.0 in the Decade of Action. The first part of the book focuses on climate-responsible entrepreneurship in support of the sustainable development of Industry 4.0. The part systematizes best practices for climate-smart green innovations across sectors of the digital economy. The third part reveals the experience of climate risk management based on smart green innovations in regions and countries. Particular attention is paid to the best practices of the European Union (EU) and the Eurasian Economic Union (EAEU). The book ends with part four, which explores ESG climate risk management and green finance in support of combating climate change. The book’s novelty is that it rethinks the environmental footprints of Industry 4.0 from the perspective of climate risks and their management. The theoretical significance of the book lies in the formation of an innovative concept of climate change risk management, in which the economy, society, nature, and technology are presented and interact effectively. The book is intended for scientists. In this book, they will find an innovative and systemic vision of smart green innovations in Industry 4.0 for climate change risk management.