This two-volume set LNICST683-684 constitutes the proceedings of the 22nd International Conference on Mobile and Ubiquitous Systems: Computing, Networking and Services, MobiQuitous 2025, held in Shanghai, China, during November 7-9, 2025. The 50 full papers and 1 poster paper included in these volumes were carefully reviewed and selected from 144 submissions. They are organized into the following topical sections:Part I: Federated Learning and Large Language Models; Secure, Reliable, and Efficient Intelligent Systems. Part II: Architectures and Algorithms for IoT; Cryptographic Schemes; Posters & Demos.