Next Generation Probiotics: Natural Therapeutics presents a comprehensive and forward-looking exploration of probiotics as scientifically grounded natural therapeutics in modern health and disease management. Building on advances in microbiome science, biotechnology, and computational biology, this volume examines how next-generation probiotics are discovered, designed, evaluated, and applied. The book bridges foundational probiotic research with emerging technologies such as machine learning, genomics, and genetic engineering, highlighting what distinguishes next-generation probiotics from traditional formulations. This edition expands its scope to reflect rapid developments in probiotic science and translational applications. It integrates insights from probiotic genomics, CRISPR-Cas9 technology, microbiota-targeted foods, and personalized microbiome-based nutrition. By addressing disease-specific, strain-specific, and host-specific effects, the book provides a holistic view of how probiotics can be optimized for therapeutic efficacy. Contributions from experts across bioinformatics, microbiology, clinical research, and food science ensure a multidisciplinary and evidence-based perspective. Key FeaturesDetailed coverage of machine learning applications in probiotic development and fermented dairy products (new to this edition)In-depth discussion of probiotic genomics, cancer associations, and CRISPR-Cas9–based strain improvementExploration of emerging probiotic candidates, including Akkermansia, Faecalibacterium, Ruminococcus, and butyrate-producing microbesComprehensive overview of novel probiotic classes such as postbiotics, parabiotics, pharmacobiotics, and immunobiotics (expanded in this edition)Practical insights into challenges in probiotic selection, regulation, stress tolerance, and personalized nutrition strategiesBringing together fundamental science and applied research, Next Generation Probiotics: Natural Therapeutics serves as an essential resource for researchers, clinicians, nutritionists, food technologists, and graduate students. It is particularly valuable for those interested in microbiome-based therapeutics, functional foods, and personalized health solutions, offering both conceptual frameworks and real-world relevance for advancing probiotic research and application.