This book constitutes the refereed proceedings of the 12th International Conference on Culture and Computing, C&C 2024, held as part of the 26th International Conference on Human-Computer Interaction, HCI International 2024, which took place in Washington DC, USA, during June 29 – July 4, 2024. The total of 1271 papers and 309 posters included in the HCII 2023 proceedings was carefully reviewed and selected from 5108 submissions. The proceedings focus on topics related to user experience design for seamless cultural experiences, technology, art, and culture, innovations in digital cultural representation, and biomodernism and cultural computing.