This book constitutes the refereed proceedings of the 13th International Conference on Culture and Computing, held as part of the 27th International Conference, HCI International 2025, which took place in Gothenburg, Sweden, during June 22–27, 2025. The total of 1430 papers and 355 posters included in the HCII 2025 proceedings was carefully reviewed and selected from 7972 submissions. Two volumes of the HCII 2025 proceedings are dedicated to this year’s edition of the C&C conference:Part I focuses on topics related to Interactive Cultural Experiences and Traditional Craft Preservation, AI-empowered Art and Computational Creativity, and Virtual, Augmented, and Mixed Reality for Cultural Heritage. Part II focuses on topics related to Interactive Media, Embodied Cognition, and Digital Communication in Cultural Experiences; Health and Well-Being; and Bie-Modernism and Cultural Computing.